by Addiction Research Division, Department of Pharmacology, University of Toronto in Toronto .
Written in English
|Statement||[by] H. Kalant, A.E. LeBlanc [and] R.J. Gibbins.|
|Contributions||LeBlanc, Alphonse E., University of Toronto. Department of Pharmacology. Addiction Research Division.|
Rationale. Alcohol effects on behavioral and cognitive mechanisms influence impaired driving performance and decisions to drive after drinking (Barry ; Moskowitz and Robinson ).To date, research has focused on the ascending limb of the blood alcohol curve, and there is little understanding of how acute tolerance to impairment of these mechanisms might influence driving behavior on the Cited by: Tolerance is a decrease in response to a drug that is used repeatedly. Resistance is development of the ability to withstand the previously destructive effect of a drug by microorganisms or tumor cells. Examples of drugs that result in tolerance include alcohol and . Variations of Chen's ‘before-versus-after’ technique have become standard for determining if behavioral factors play a role in the development of tolerance. An example of one variation was provided by Carlton and Wolgin () who studied effects of d-amphetamine on milk drinking by rats. Three groups of rats were allowed to drink milk once Cited by: A more limited body of literature shows that stress may increase alcohol consumption, but this effect depends heavily on a number of factors, including the stressor and the alcohol-drinking model used, as well as the species, sex, and age of the experimental animals. 4 Studies that show stress-induced escalation of alcohol drinking in rodents.
Tolerance is important because it is one of the primary determinants of increased alcohol drinking. When one becomes tolerant, they can no longer feel the effects of the drug, or feel a decreased effect at a given dose and this makes them increase their consumption - this can lead to the development or worsening of alcohol dependence problems. BEHAVIORAL TOLERANCE In everyday language, Tolerance implies the ability to withstand something. In pharmacology, the term tolerance is close to this meaning. To understand the technical meaning of the word, however, requires an understanding of the concept of the potency of a drug. A drug's potency is expressed in terms of the amount (the dose) of the drug needed to produce a certain . "ALCOHOL TOLERANCE AND SOCIAL DRINKING is destined to be the classic work on tolerance in social drinkers. Professor Vogel's elegant research makes for fascinating reading. In my view, the book is a gold mine of new ideas and is a `must' for anyone interested in human drinking behavior. -- Alan Marlatt, Ph.D., University of Washington. These animal models have characteristics that mirror in many respects human alcohol addiction; the animals show tolerance development, and pharmacological agents (e.g., naltrexone, an opiate antagonist) that reduce alcohol consumption in humans also reduce consumption in the animals (Li and McBride, ; Schuckit, ).
By Ian Fleming - Book The Pharmacology Of Alcohol And Alcohol Dependence Alcohol And Alcoholism, the second volume in the alcohol and alcoholism series it focuses on the pharmacologic mechanisms underlying the development of alcoholism the first section on basic. All of these factors ultimately result in A ALCOHOL PHARMACOLOGY. 2 prolong the behavioral effects of alcohol. Those drugs that block the effects of GABA have the opposite effects. For L. and Brick, J., Pharmacology of Alcohol. The Pharmacology of Ethanol, In: International Encyclopedia of Pharmacological Therapeutics. Alcohol Alcohol abuse is a pattern of problem drinking that results in health consequences, social, problems, or both. However, alcohol dependence, or alcoholism, refers to a disease that is characterized by abnormal alcohol-seeking behavior that leads to impaired control over drinking Short-term effects of alcohol use include. The process of tolerance development is reversible (e.g., through a drug holiday) and can involve both physiological factors and psychological factors.  One may also develop drug tolerance to side effects,  in which case tolerance is a desirable characteristic.